Antimicrobial resistance (AMR) is a global problem hindering treatment of bacterial
infections, rendering many aspects of modern medicine less effective. AMR genes (ARGs) …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

In recent years, the explosive spread of antibiotic resistance determinants among
pathogenic, commensal, and environmental bacteria has reached a global dimension …

The targeting of one mRNA in the transcriptome requires small molecules that bind with
substantial affinity and specificity. As such, compounds with specificity for individual RNA …

Biosynthetic studies of aminoglycoside antibiotics have progressed remarkably during the
last decade. Many biosynthetic gene clusters for aminoglycoside antibiotics including …

Antibiotic resistance increases the likelihood of death from infection by common pathogens
such as Escherichia coli and Klebsiella pneumoniae in developed and developing countries …

Herein, we report the development of a microarray platform to select RNA motif− ligand
interactions that allows simultaneous screening of both RNA and chemical space. We used …

Many multidrug-resistant bacterial pathogens harbor large plasmids that encode proteins
conferring resistance to antibiotics. Although the acquisition of these plasmids often enables …

Deoxystreptamine (2DOS) is the unique chemically stable aminocyclitol scaffold of clinically
important aminoglycoside antibiotics such as neomycin, kanamycin, and gentamicin, which …

BtrN encoded in the butirosin biosynthetic gene cluster possesses a CXXXCXXC motif
conserved within the radical S-adenosyl methionine (SAM) superfamily. Its gene disruption …