Coacervate droplets for synthetic cells

Z Lin, T Beneyton, JC Baret, N Martin - Small Methods, 2023 - Wiley Online Library
The design and construction of synthetic cells–human‐made microcompartments that mimic
features of living cells–have experienced a real boom in the past decade. While many efforts …

Present and future of synthetic cell development

KP Adamala, M Dogterom, Y Elani, P Schwille… - … Reviews Molecular Cell …, 2024 - nature.com
Scientists are captivated by the prospect of creating a fully synthetic cell, offering the
potential to revolutionize biology, medicine and biotechnology. In this Viewpoint, a panel of …

Curcumin delivery using tetrahedral framework nucleic acids enhances bone regeneration in osteoporotic rats

L Bai, M Feng, Q Li, Y Zhao, G Zhang, Z Cai… - Chemical Engineering …, 2023 - Elsevier
Osteoporosis is an age-related disorder characterized by progressive bone loss and
impaired bone regeneration following surgery. The key to the treatment of osteoporosis is …

DNA droplets for intelligent and dynamical artificial cells: From the viewpoint of computation and non-equilibrium systems

M Takinoue - Interface Focus, 2023 - royalsocietypublishing.org
Living systems are molecular assemblies whose dynamics are maintained by non-
equilibrium chemical reactions. To date, artificial cells have been studied from such physical …

Temporally controlled multistep division of DNA droplets for dynamic artificial cells

T Maruyama, J Gong, M Takinoue - Nature Communications, 2024 - nature.com
Synthetic droplets mimicking bio-soft matter droplets formed via liquid-liquid phase
separation (LLPS) in living cells have recently been employed in nanobiotechnology for …

Light-controlled growth of DNA organelles in synthetic cells

S Agarwal, M Dizani, D Osmanovic… - Interface …, 2023 - royalsocietypublishing.org
Living cells regulate many of their vital functions through dynamic, membraneless
compartments that phase separate (condense) in response to different types of stimuli. In …

Nucleic acid liquids

GR Abraham, AS Chaderjian… - Reports on Progress …, 2024 - iopscience.iop.org
The confluence of recent discoveries of the roles of biomolecular liquids in living systems
and modern abilities to precisely synthesize and modify nucleic acids (NAs) has led to a …

Liquid DNA coacervates form porous capsular hydrogels via viscoelastic phase separation on microdroplet interface

M Morita, T Sakamoto, SM Nomura… - Advanced Materials …, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS) droplets of biopolymers are known as functional
microdroplets in living cells and have recently been used to construct protocells and artificial …

Amphiphiles formed from synthetic DNA-nanomotifs mimic the stepwise dispersal of transcriptional clusters in the cell nucleus

X Tschurikow, A Gadzekpo, MP Tran, R Chatterjee… - Nano Letters, 2023 - ACS Publications
Stem cells exhibit prominent clusters controlling the transcription of genes into RNA. These
clusters form by a phase-separation mechanism, and their size and shape are controlled via …

Spontaneous Formation of Uniform Cell‐Sized Microgels through Water/Water Phase Separation

M Shono, G Honda, M Yanagisawa, K Yoshikawa… - Small, 2023 - Wiley Online Library
In this study, a one‐step method is discussed for producing uniform cell‐sized microgels
using glass capillaries filled with a binary polymer blend of polyethylene glycol (PEG) and …