Sex differences in hypertension: where we have been and where we are going

LA Ramirez, JC Sullivan - American journal of hypertension, 2018 - academic.oup.com
While it has been known since the 1940s that men have greater increases in blood pressure
(BP) compared with women, there have been intense efforts more recently to increase …

Renin-angiotensin system and sex differences in COVID-19: a critical assessment

MC Chappell - Circulation Research, 2023 - Am Heart Assoc
The current epidemic of corona virus disease (COVID-19) has resulted in an immense
health burden that became the third leading cause of death and potentially contributed to a …

Sex differences in hypertension: lessons from spontaneously hypertensive rats (SHR)

AA Elmarakby, JC Sullivan - Clinical Science, 2021 - portlandpress.com
Although numerous clinical and experimental studies have clearly identified a sexual
dimorphism in blood pressure control, the mechanism (s) underlying gender differences in …

Egg white–derived antihypertensive peptide IRW (Ile‐Arg‐Trp) reduces blood pressure in spontaneously hypertensive rats via the ACE2/ang (1‐7)/mas receptor Axis

W Liao, H Fan, ST Davidge, J Wu - Molecular nutrition & food …, 2019 - Wiley Online Library
Scope It is found in the previous study that egg‐white‐derived antihypertensive peptide Ile‐
Arg‐Trp (IRW) upregulated angiotensin converting enzyme 2 (ACE2) in spontaneously …

The ACE2/Ang (1–7)/MasR axis as an emerging target for antihypertensive peptides

W Liao, J Wu - Critical Reviews in Food Science and Nutrition, 2021 - Taylor & Francis
Food protein-derived bioactive peptides, particularly antihypertensive peptides, are
important constituents of functional foods or nutraceuticals. Most antihypertensive are …

Differences in angiotensin (1–7) between men and women

JC Sullivan, P Rodriguez-Miguelez… - American Journal …, 2015 - journals.physiology.org
In experimental animal models of hypertension, angiotensin (1–7)[ANG-(1–7)] is higher in
females compared with males; however, it is less clear whether the same applies to humans …

Sex differences in regulation of blood pressure

JF Reckelhoff - Sex-Specific Analysis of Cardiovascular Function, 2018 - Springer
Hypertension is one of the leading risk factors for cardiovascular disease, myocardial
infarction, and stroke. There are gender differences in the prevalence of hypertension and in …

Relationship between circulating levels of angiotensin-converting enzyme 2-angiotensin-(1–7)-MAS axis and coronary heart disease

X Zhou, P Zhang, T Liang, Y Chen, D Liu, H Yu - Heart and vessels, 2020 - Springer
As a counter-regulatory arm of the renin angiotensin system (RAS), the angiotensin-
converting enzyme 2-angiotensin-(1–7)-MAS axis (ACE2-Ang-(1–7)-MAS axis) plays a …

Sex and gender differences in hypertensive kidney injury

JC Sullivan, EE Gillis - American Journal of Physiology …, 2017 - journals.physiology.org
Hypertension is a complex, multifaceted disorder, affecting~ 1 in 3 adults in the United
States. Although hypertension occurs in both men and women, there are distinct sex …

Impact of ACE2 gene polymorphism on antihypertensive efficacy of ACE inhibitors

YY Chen, D Liu, P Zhang, JC Zhong… - Journal of Human …, 2016 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2), a newly discovered member of renin–
angiotensin–aldosterone system, counterbalances the actions of angiotensin-converting …