Monoclonal antibodies (mAbs) have become one of the most important classes of
biopharmaceutical products, and they continue to dominate the universe of …

Monoclonal antibodies (mAbs) are often selected from antigen-specific single B cells
derived from different hosts, which are notably short-lived in ex vivo culture conditions and …

The ability to design functional sequences and predict effects of variation is central to protein
engineering and biotherapeutics. State-of-art computational methods rely on models that …

Single-cell RNA-seq can precisely resolve cellular states, but applying this method to low-
input samples is challenging. Here, we present Seq-Well, a portable, low-cost platform for …

Droplet microfluidics has revolutionized the study of single cells. The ability to
compartmentalize cells within picoliter droplets in microfluidic devices has opened up a wide …

B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to
infection and vaccination, but it provides limited information about the antigen specificity of …

Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery
of useful antibodies for therapeutic or research purposes. We present a method for high …

Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell
receptor (TR) gene rearrangements for clonality assessment, marker identification and …

The unabated progress in next-generation sequencing technologies is fostering a wave of
new genomics, epigenomics, transcriptomics and proteomics technologies. These …