Mitochondria control cellular fate by various mechanisms and are key drivers of cellular
metabolism. Although the main function of mitochondria is energy production, they are also …

Mitochondrial disorders have emerged as a common cause of inherited disease, but are
traditionally viewed as being difficult to diagnose clinically, and even more difficult to …

Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury. 2-propyl-4-
pentenoic acid (Δ 4 VPA), a metabolite of VPA, has been implicated in VPA-induced …

Valproic acid (VPA) and its salts are psychotropic drugs that are widely used in neurological
diseases (epilepsy, neuropathic pain, migraine, etc.) and psychiatric disorders …

Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …

Valproic acid (VPA) is a widely prescribed antiepileptic drug, which may cause steatosis in
the liver. Oxidative stress is associated with the progression of VPA-induced hepatic …

Introduction: Valproic acid (VPA) is an antiepileptic drug extensively used for treating partial
and generalised seizures, acute mania and as prophylaxis for bipolar disorder. Drug …

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
some of the biggest public health challenges due to their spread and increasing incidence …

Abstract Drug-Induced Liver Injury (DILI) and herb Induced Liver Injury (HILI) continues to
pose a substantial challenge in both clinical practice and drug development, representing a …

The development of bio-based nanoparticles (NPs) as drug containers is of increasing
interest to circumvent several obstacles in drug therapy such as rapid drug metabolization …