Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …

Cellular senescence and chronic inflammation in response to aging are considered to be
indicators of brain aging; they have a great impact on the aging process and are the main …

The blood–brain barrier, which is formed by tightly interconnected microvascular endothelial
cells, separates the brain from the peripheral circulation. Together with other central nervous …

Background Huntington's disease (HD) is an autosomal dominant disease caused by an
abnormally high number of CAG repeats at the huntingtin-encoding gene, HTT. This genetic …

Neurodegenerative diseases are prevalent and currently incurable conditions that
progressively impair cognitive, behavioral, and psychiatric functions of the central or …

Ferroptosis is a newly discovered non-apoptotic and iron-dependent type of cell death.
Ferroptosis mainly takes place owing to the imbalance of anti-oxidation and oxidation in the …

Abstract “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive
neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6) …

We previously identified solute carrier family 7 member 2 (SLC7A2) as one of the top
upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high affinity for l …

Neurodegenerative disorders (NDs) are among the most common causes of death across
the globe. NDs are characterized by progressive damage to CNS neurons, leading to …