Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …

Mitochondria has emerged as a critical ruler of metabolic reprogramming in immune
responses and inflammation. In the context of colitogenic T cells and IBD, there has been …

Abstract Store-Operated Ca 2+ entry (SOCE) is recognized as a key mechanism in muscle
physiology necessary to refill intracellular Ca 2+ stores during sustained muscle activity. For …

Immune cells-enhanced immunotherapy exhibits unprecedented overall survival-
prolongation even curable in some cancer patients. Although so, most of the patients show …

IBD is an uncontrolled inflammatory condition of the gastrointestinal tract, which mainly
manifests in two forms: ulcerative colitis (UC) and Crohn's disease (CD). The pathogenesis …

Three new phenanthrene derivatives (1, 2, 4), one new fluorenone (3), and four known
compounds (5–8) were isolated from the ethyl acetate extract of Dendrobium crumenatum …

Abstract Background Imbalances in Th1/Th2 and Th17/Treg immune axes, coupled with
disruptions in the gut microbiota (GM), play a pivotal role in the pathogenesis of …

The ORAI proteins serve as crucial pore-forming subunits of calcium-release-activated
calcium (CRAC) channels, pivotal in regulating downstream calcium-related signaling …

Ethnopharmacological relevance Chinese herbal medicine Gegen Qinlian Decoction (GQD)
has been clinically shown to be an effective treatment of ulcerative colitis (UC) in China …