Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene
coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are …

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides
a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …

Oncogene-induced DNA damage elicits genomic instability in epithelial cancer cells, but
apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological …

In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence.
Alternatively, cells enter senescence in response to inappropriate growth signals such as …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as
humans, plants, and insects. These proteins play a key role in regulating advancement of …