Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic
pathways and transformations. Emerging evidence reveals that cells monitor the levels of …

Nature has produced intricate machinery to covalently diversify the structure of proteins after
their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …

In living systems, the chemical space and functional repertoire of proteins are dramatically
expanded through the post-translational modification (PTM) of various amino acid residues …

Although the syntheses of novel and diverse peptides rely mainly on traditional coupling
using unnatural amino acids, postsynthetic modification of peptides could provide a …

Sirtuins are NAD+-dependent enzymes universally present in all organisms, where they play
central roles in regulating numerous biological processes. Although early studies showed …

The protein kinase CK2 (CK2) family encompasses a small number of acidophilic
serine/threonine kinases that phosphorylate substrates involved in numerous biological …

Male germ cell differentiation is a highly regulated multistep process initiated by the
commitment of progenitor cells into meiosis and characterized by major chromatin …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …