Design of drug delivery systems containing artemisinin and its derivatives
BA Aderibigbe - Molecules, 2017 - mdpi.com
Artemisinin and its derivatives have been reported to be experimentally effective for the
treatment of highly aggressive cancers without developing drug resistance, they are useful …
treatment of highly aggressive cancers without developing drug resistance, they are useful …
Acridine-based antimalarials—from the very first synthetic antimalarial to recent developments
M Fonte, N Tassi, P Gomes, C Teixeira - Molecules, 2021 - mdpi.com
Malaria is among the deadliest infectious diseases in the world caused by Plasmodium
parasites. Due to the high complexity of the parasite's life cycle, we partly depend on …
parasites. Due to the high complexity of the parasite's life cycle, we partly depend on …
Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as
convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl) isoxazole …
convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl) isoxazole …
Synergistic interaction of N‐3‐Br‐benzyl‐noscapine and docetaxel abrogates oncogenic potential of breast cancer cells
Noscapine, an opium alkaloid, was discovered to bind tubulin, arrest dividing cells at
mitosis, and selectively induce apoptosis to cancer cells. N‐3‐Br‐Benzyl‐Noscapine (Br‐Bn …
mitosis, and selectively induce apoptosis to cancer cells. N‐3‐Br‐Benzyl‐Noscapine (Br‐Bn …
[HTML][HTML] Repurposing of existing therapeutics to combat drug-resistant malaria
In the era of drug repurposing, speedy discovery of new therapeutic options for the drug-
resistant malaria is the best available tactic to reduce the financial load and time in the drug …
resistant malaria is the best available tactic to reduce the financial load and time in the drug …
Chemical Hybridization Approaches Applied to Natural and Synthetic Compounds for the Discovery of Drugs Active Against Neglected Tropical Diseases
Within the drug discovery process, serendipity is often counterposed to the rational design
approach, in terms of both logic and chronology. Moving toward the concept of hybrid …
approach, in terms of both logic and chronology. Moving toward the concept of hybrid …
Some Application of Selective Toxicities of Acridines
J Ježek, J Hlaváček, J Šebestík, J Ježek… - … Applications of Acridines …, 2017 - Springer
Inhibitions of pathogen specific enzymes with acridines play roles in cure of various
diseases. Thus, acridines can serve for treatment of various tropical diseases caused by …
diseases. Thus, acridines can serve for treatment of various tropical diseases caused by …