Imaging collagen in scar tissue: developments in second harmonic generation microscopy for biomedical applications

L Mostaço-Guidolin, NL Rosin, TL Hackett - International journal of …, 2017 - mdpi.com
The ability to respond to injury with tissue repair is a fundamental property of all multicellular
organisms. The extracellular matrix (ECM), composed of fibrillar collagens as well as a …

Label-free multiphoton microscopy: much more than fancy images

G Borile, D Sandrin, A Filippi, KI Anderson… - International Journal of …, 2021 - mdpi.com
Multiphoton microscopy has recently passed the milestone of its first 30 years of activity in
biomedical research. The growing interest around this approach has led to a variety of …

Optical microscopy and the extracellular matrix structure: a review

JJA Poole, LB Mostaço-Guidolin - Cells, 2021 - mdpi.com
Biological tissues are not uniquely composed of cells. A substantial part of their volume is
extracellular space, which is primarily filled by an intricate network of macromolecules …

Defective fibrillar collagen organization by fibroblasts contributes to airway remodeling in asthma

LB Mostaço-Guidolin, ET Osei, J Ullah… - American journal of …, 2019 - atsjournals.org
Rationale: Histologic stains have been used as the gold standard to visualize extracellular
matrix (ECM) changes associated with airway remodeling in asthma, yet they provide no …

Collagen morphology and texture analysis: from statistics to classification

LB Mostaço-Guidolin, ACT Ko, F Wang, B Xiang… - Scientific reports, 2013 - nature.com
In this study we present an image analysis methodology capable of quantifying
morphological changes in tissue collagen fibril organization caused by pathological …

Kerr-lens mode locking of a diode-pumped Yb: KGW laser using an additional intracavity Kerr medium

R Akbari, A Major - Laser Physics Letters, 2018 - iopscience.iop.org
Kerr-lens mode-locked operation of a Yb: KGW laser pumped by a multimode laser diode
with the help of an additional Kerr medium is reported. With an enhanced Kerr lensing effect …

High power continuous-wave dual-wavelength alexandrite laser

S Ghanbari, A Major - Laser Physics Letters, 2017 - iopscience.iop.org
A high power dual-wavelength alexandrite (Cr: BeAl 2 O 4) laser using a single plate
birefringent filter (BRF) was demonstrated. Using a 6 mm thick BRF, dual-wavelength output …

Machine learning-enabled cancer diagnostics with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific reports, 2022 - nature.com
The extracellular matrix (ECM) collagen undergoes major remodeling during tumorigenesis.
However, alterations to the ECM are not widely considered in cancer diagnostics, due to …

High-power diode-pumped Kerr-lens mode-locked bulk Yb: KGW laser

R Akbari, A Major - Applied Optics, 2017 - opg.optica.org
A high-power (> 1 W) pure Kerr-lens mode-locked bulk Yb: KGW laser with multimode fiber-
coupled diode pumping was demonstrated. The laser delivered 240 fs pulses with 2.3 W of …

Unsupervised determination of lung tumor margin with widefield polarimetric second-harmonic generation microscopy

K Mirsanaye, L Uribe Castaño, Y Kamaliddin… - Scientific Reports, 2022 - nature.com
The extracellular matrix (ECM) is amongst many tissue components affected by cancer,
however, morphological changes of the ECM are not well-understood and thus, often …