In the early nineties, few years before the birth of Europace, the clinical and scientific world
of familial arrhythmogenic conditions was revolutionized by the identification of the first …

In the last 25 years, EP Europace has published more than 300 basic and translational
science articles covering different arrhythmia types (ranging from atrial fibrillation to …

Aims SCN5A mutations are associated with various cardiac phenotypes, including long QT
syndrome type 3 (LQT3), Brugada syndrome (BrS), and cardiac conduction disease (CCD) …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …

In the past 20 years, genetic variants in SCN5A encoding the cardiac voltage-gated sodium
channel Nav1. 5 have been linked to a range of inherited cardiac arrhythmias: variants …

Abstract Background Multifocal ectopic Purkinje-related premature contractions (MEPPCs)
are associated with SCN5A variants. However, it is not well understood why Purkinje fibers …

Aims Opioids are associated with increased risk of sudden cardiac death. This may be due
to their effects on the cardiac sodium channel (Nav1. 5) current. In the present study, we aim …

A well-balanced ion channel trafficking machinery is paramount for the normal
electromechanical function of the heart. Ion channel variants and many drugs can alter the …

Background: We identified a novel SCN5A variant, E171Q, in a neonate with very frequent
ectopy and reduced ejection fraction which normalized after arrhythmia suppression by …

The efficacy of quinidine in multifocal ectopic Purkinje-related premature contractions
(MEPPC) had been reported previously. However, quinidine sometimes causes side effects …