Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies* |
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This review focuses on recent advances in the structure-function relationships of thyroid-
stimulating hormone (TSH) and its receptor. TSH is a member of the glycoprotein hormone …

In glycoprotein hormone receptors, a subfamily of rhodopsin-like G protein-coupled
receptors, the recognition and activation steps are carried out by separate domains of the …

The thyroid-stimulating hormone receptor (TSHR) is a G protein–linked, 7–transmembrane
domain (7-TMD) receptor that undergoes complex posttranslational processing unique to …

A total of 33 different autonomous hot nodules from 31 patients, originating mainly from
Belgium, were investigated for the presence of somatic mutations in the TSH receptor and …

Thyroid gland agenesis is the most common cause of congenital hypothyroidism and is
usually sporadic. We investigated a brother and sister from consanguineous parents …

The thyrotropin (TSH) receptor plays a preeminent role in thyroid physiology and disease.
TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth …

The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of
family AG protein-coupled receptors. The TSHR is of great importance for the growth and …

The generation of Abs recognizing the native structure of the human thyrotropin receptor
(hTSHR) has been difficult because there is currently no method allowing the purification of …

Graves disease is directly caused by thyroid-stimulating autoantibodies (TSAb's) that
activate the thyrotropin receptor (TSHR). We observed upon flow cytometry using intact cells …