Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all
mammalian cells and usually covalently attached to proteins, forming proteoglycans. They …

Angiogenesis, the process of formation of new blood vessel from pre-existing ones, is
involved in various intertwined pathological processes including virus infection …

Trace elements play critical roles in angiogenesis events. The effects of nitrogen, iron,
selenium, phosphorus, gold, and calcium were discussed in part I. In part II, we evaluated …

Glycosaminoglycans (GAGs) are an important component of the tumor microenvironment
(TME). GAGs can interact with a variety of binding partners and thereby influence cancer …

Nature uses sulfation of endogenous and exogenous molecules mainly to avoid potential
toxicity. The growing importance of natural sulfated molecules, as modulators of a number of …

Selective targeting of cancer stem-like cells (CSCs) is a paradigm-shifting approach. We
hypothesized that CSCs can be targeted by interfering with functions of sulfated …

Glycosaminoglycans (GAGs) are key natural biopolymers that exhibit a range of biological
functions including growth and differentiation. Despite this multiplicity of function, natural …

Factor XIa (fXIa) is being recognized as a prime target for developing safer anticoagulants.
To discover synthetic, small, allosteric inhibitors of fXIa, we screened an in-house, unique …

The molecular mechanism of herpes simplex virus (HSV) entry and the associated
inflammatory response in the nervous system remain poorly understood. Using mouse …