Acetazolamide use in severe chronic obstructive pulmonary disease. Pros and cons

R Adamson, ER Swenson - Annals of the American Thoracic Society, 2017 - atsjournals.org
Acetazolamide is a carbonic anhydrase (CA) inhibitor sometimes used as a respiratory
stimulant for patients with chronic obstructive pulmonary disease (COPD) with the goal of …

Progesterone: review of safety for clinical studies.

NV Goletiani, DR Keith, SJ Gorsky - Experimental and clinical …, 2007 - psycnet.apa.org
Progesterone is a steroid hormone that is important for reproductive function. Progesterone
is used in a number of clinical applications and has been investigated as a possible novel …

Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy

ABMMK Islam, MAAK Khan - Scientific reports, 2020 - nature.com
An incomplete understanding of the molecular mechanisms behind impairment of lung
pathobiology by COVID-19 complicates its clinical management. In this study, we analyzed …

Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis

R Gulsvik, I Skjørten, K Undhjem, L Holø… - The clinical …, 2013 - Wiley Online Library
Introduction Coexistent respiratory failure and metabolic alkalosis is a common finding.
Acidotic diuretics cause a fall in pH that may stimulate respiration. Objective The purpose of …

Enhanced Oral Bioavailability of Progesterone in Bilosome Formulation: Fabrication, Statistical Optimization, and Pharmacokinetic Study

R Maheshwari, LK Bhatt, S Wairkar - AAPS PharmSciTech, 2024 - Springer
Progesterone, a female sex steroid hormone, is highly lipophilic, leading to poor oral
bioavailability. This study aimed to develop a progesterone bilosome system to enhance its …

Effect of acetazolamide on ventilatory response in subjects with chronic mountain sickness

M Rivera-Ch, L Huicho, P Bouchet, JP Richalet… - Respiratory physiology …, 2008 - Elsevier
Although the effects of acetazolamide (ACZ) on ventilation during acute mountain sickness
are well known, there are no studies assessing its effect on ventilatory response in chronic …

Lung biopsy cells transcriptional landscape from COVID-19 patient stratified lung injury in SARS-CoV-2 infection through impaired pulmonary surfactant metabolism

ABMMK Islam, MAAK Khan - BioRxiv, 2020 - biorxiv.org
Clinical management of COVID-19 is still complicated due to the lack of therapeutic
interventions to reduce the breathing problems, respiratory complications and acute lung …

Central hypoventilation in progressive supranuclear palsy

KS Herrick, R Woltjer, T Pham… - Movement disorders …, 2017 - Wiley Online Library
Central hypoventilation, also known as Ondine's curse, results from an impairment of the
autonomic respiratory drive. It is characterized by an attenuated or absent respiratory …

Pseudocyesis in a teenager using long-term contraception

T Ayakannu, S Wordsworth, R Smith… - Journal of obstetrics …, 2007 - Taylor & Francis
Discussion Our literature search reveals only one other case of pseudocyesis associated
with the use of Depo-Provera in teenagers (Flanagan and Harel Citation 1999). Irregular …

Safety and toxicological profile of contemporary analeptics: prodigious focus on doxapram and almitrine

JK Gupta - Research Journal of Pharmacy and Technology, 2021 - indianjournals.com
Analeptics are the classes of stimulant drugs which are generally used to treat respiratory
depression particularly in case of coma and fainting. Most of them are central nervous …