The native tissues are complex structures consisting of different cell types, extracellular
matrix materials, and biomolecules. Traditional tissue engineering strategies have not been …

Fetuin-A is a heterodimeric plasma glycoprotein containing an A-chain of 282 amino acids
and a B-chain of 27 amino acid residues linked by a single inter-disulfide bond. It is …

Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming
growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context …

The glucocorticoid (GC) receptor (GR), when liganded to GC, activates transcription through
direct binding to simple (+) GRE DNA binding sequences (DBS). GC-induced direct …

Ectopic calcification is a frequent complication of many degenerative diseases. Here we
identify the serum protein α2–Heremans-Schmid glycoprotein (Ahsg, also known as fetuin …

Background Vascular calcification is the most prominent underlying pathological finding in
patients with uraemia, and is a predictor of mortality in this population. Fetuin-A (α 2 …

The final step of biomineralization is a chemical precipitation reaction that occurs
spontaneously in supersaturated or metastable salt solutions. Genetic programs direct …

Genetic evidence from mutant mice suggests that α 2-HS glycoprotein/fetuin-A (Ahsg) is a
systemic inhibitor of precipitation of basic calcium phosphate preventing unwanted …

The bone matrix is constantly remodeled by bone-resorbing osteoclasts and bone-forming
osteoblasts. These two cell types are fundamentally different in terms of progenitor cells …

Fetuins are serum proteins with diverse functions including the regulation of osteogenesis
and inhibition of unwanted mineralization. Besides the α2-Heremans and Schmid …