Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

[HTML][HTML] Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target

J Zhang, H Xiang, J Liu, Y Chen, RR He, B Liu - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Sirtuin 3 (SIRT3) is one of the most prominent deacetylases that can regulate
acetylation levels in mitochondria, which are essential for eukaryotic life and inextricably …

[HTML][HTML] Mitochondrial sirtuins, metabolism, and aging

Z Ji, GH Liu, J Qu - Journal of Genetics and Genomics, 2022 - Elsevier
Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Why is longevity still a scientific mystery? Sirtuins—past, present and future

P Ziętara, M Dziewięcka, M Augustyniak - International Journal of …, 2022 - mdpi.com
The sirtuin system consists of seven highly conserved regulatory enzymes responsible for
metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is …

The effect of caloric restriction and fasting on cancer

M Alidadi, M Banach, PC Guest, S Bo… - Seminars in Cancer …, 2021 - Elsevier
Cancer is one of the most frequent causes of worldwide death and morbidity and is a major
public health problem. Although, there are several widely used treatment methods including …

Pine nut antioxidant peptides ameliorate the memory impairment in a scopolamine-induced mouse model via SIRT3-induced synaptic plasticity

H Lu, L Fang, J Wang, F Zhao, C Liu, Y Gao, J Liu… - Food & Function, 2021 - pubs.rsc.org
This study aimed to investigate the effects of a pine nut albumin hydrolysate (fraction< 3
kDa) and of its short peptide derivative, Trp-Tyr-Pro-Gly-Lys (WYPGK), on synaptic plasticity …

Sirtfoods: new concept foods, functions, and mechanisms

OD Akan, D Qin, T Guo, Q Lin, F Luo - Foods, 2022 - mdpi.com
Sirtfood is a new concept food that compounds diets that can target sirtuins (SIRTs). SIRTs
are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases and ADP …

The role and therapeutic perspectives of Sirtuin 3 in cancer metabolism reprogramming, metastasis, and chemoresistance

QY Zhao, J Zhou, F Li, S Guo, L Zhang, J Li, Q Qi… - Frontiers in …, 2022 - frontiersin.org
Sirtuin 3 (SIRT3), the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase,
acts as a metabolic modulator mainly located in mitochondria via regulating the process of …

A “weird” mitochondrial fatty acid oxidation as a metabolic “secret” of cancer

Z Zhelev, I Aoki, D Lazarova, T Vlaykova… - Oxidative Medicine …, 2022 - Wiley Online Library
Cancer metabolism is an extensively studied field since the discovery of the Warburg effect
about 100 years ago and continues to be increasingly intriguing and enigmatic so far. It has …

Succinate-directed approaches for Warburg effect-targeted cancer management, an alternative to current treatments?

A Casas-Benito, S Martínez-Herrero, A Martínez - Cancers, 2023 - mdpi.com
Simple Summary One hundred years ago, it was discovered that some cancer cells have a
different metabolism from normal cells. This alternative metabolism is called the Warburg …