Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …

Along with compounds from terrestrial microorganisms, the constituents of higher plants
have provided a substantial number of the natural product-derived drugs used currently in …

Coronaviruses (CoV) and picornaviruses are plus-strand RNA viruses that use 5′ cap-
dependent and cap-independent strategies, respectively, for viral mRNA translation …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Introduction Ribosome biogenesis is commonly up-regulated to satisfy the increased
anabolic demands associated with malignant transformation and tumor growth. Many …

Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling
cell survival, metabolism, and inflammation. Several drugs that target PHBs have been …

Activation of the ER stress response is associated with malignant progression of B cell
chronic lymphocytic leukemia (CLL). We developed a murine CLL model that lacks the ER …

Background Protein synthesis is tightly regulated and alterations to translation are
characteristic of many cancers. Translation regulation is largely exerted at initiation through …

Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …

Transcription and translation are fundamental cellular processes that govern the protein
production of cells. These processes are generally up regulated in cancer cells, to maintain …