The pathogenesis of African trypanosomiasis
E Pays, M Radwanska, S Magez - Annual Review of Pathology …, 2023 - annualreviews.org
African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …
A human apolipoprotein L with detergent-like activity kills intracellular pathogens
INTRODUCTION In the arms race between pathogen and host, infecting microbes often
escape extracellular defense mechanisms to exploit the nutrient-rich intracellular …
escape extracellular defense mechanisms to exploit the nutrient-rich intracellular …
Human inborn errors of immunity to infection affecting cells other than leukocytes: from the immune system to the whole organism
Highlights•Cells other than leukocytes can be essential for protective immunity in
humans.•Human inborn errors of immunity to infection can affect non-professional cells …
humans.•Human inborn errors of immunity to infection can affect non-professional cells …
APOL1 C-terminal variants may trigger kidney disease through interference with APOL3 control of actomyosin
S Uzureau, L Lecordier, P Uzureau, D Hennig… - Cell reports, 2020 - cell.com
The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …
[HTML][HTML] Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis
Y Lv, WT Tang, YQ Xu, WJ Chang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Aim: Colorectal cancer (CRC) is the leading cause of cancer associated death worldwide
and immune checkpoint blockade therapy only benefit a small set of CRC patients. Tumor …
and immune checkpoint blockade therapy only benefit a small set of CRC patients. Tumor …
African trypanosomes
African trypanosomes cause human African trypanosomiasis and animal African
trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most …
trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most …
Apolipoproteins L1 and L3 control mitochondrial membrane dynamics
L Lecordier, P Heo, JH Graversen, D Hennig… - Cell reports, 2023 - cell.com
Summary Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the
membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular …
membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular …
Genetic risk of APOL1 and kidney disease in children and young adults of African ancestry
KJ Reidy, R Hjorten, RS Parekh - Current opinion in pediatrics, 2018 - journals.lww.com
APOL1 explains almost 70% of the excess risk of kidney disease in those of African descent,
and is common in children with glomerular disease. An evolving understanding of the …
and is common in children with glomerular disease. An evolving understanding of the …
Ultrastructural Changes of the Mitochondrion During the Life Cycle of Trypanosoma brucei
The mitochondrion is crucial for ATP generation by oxidative phosphorylation, among other
processes. Cristae are invaginations of the mitochondrial inner membrane that house nearly …
processes. Cristae are invaginations of the mitochondrial inner membrane that house nearly …
Intratumor APOL3 delineates a distinctive immunogenic ferroptosis subset with prognosis prediction in colorectal cancer
Y Lv, P Zheng, Y Mao, Y Xu, W Chang, Q Lin… - Cancer …, 2024 - Wiley Online Library
With the essential role of lipid transporting signaling in cancer‐related immunity,
apolipoprotein L3 (APOL3), a member of the apolipoprotein L gene family, demonstrated …
apolipoprotein L3 (APOL3), a member of the apolipoprotein L gene family, demonstrated …