The gold standard in the repair of bony defects is autologous bone grafting, even though it
has drawbacks in terms of availability and morbidity at the harvesting site. Bone‐tissue …

Direct injection is a minimally invasive method of stem cell transplantation for numerous
injuries and diseases. However, despite its promising potential, its clinical translation is …

Clefts of the lip and/or palate are the most prevalent orofacial birth defects occurring in about
1: 700 live human births worldwide. Early postnatal surgical interventions are extensive and …

The balance of redox homeostasis is key to stem cell maintenance and differentiation.
However, this balance is disrupted by the overproduced reactive oxygen species (ROS) in …

Human mesenchymal stromal cells (hMSCs) are increasingly used in regenerative medicine
for restoring worn-out or damaged tissue. Newly engineered tissues need to be properly …

Osteogenic differentiation of multipotent mesenchymal stem cells (MSCs) plays a crucial role
in bone remodeling. Numerous studies have described the deleterious effect of iron …

Tissue engineering of large bone defects is approached through implantation of autologous
osteogenic cells, generally referred to as multipotent stromal cells or mesenchymal stem …

Background: Although strong efforts have been made over the last decade to introduce stem
cell and tissue engineering treatment strategies to the field of orthopaedics, only few clinical …

There is a demonstrated clinical need for alternatives of autologous fresh bone graft with
excellent biological performance in osteoconductivity, osteoinductivity, and osteogenicity …

Electrospun fibrous membranes provide suitable physical anti-adhesion barriers for
reducing tissue anti-adhesion following surgery. However, often during the biodegradation …