For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Because of the high demand of organs, the usage of marginal grafts has increased. These
marginal organs have a higher risk of developing ischemia-reperfusion injury, which can …

Ex vivo normothermic machine perfusion (NMP) of donor kidneys prior to transplantation
provides a platform for direct delivery of cellular therapeutics to optimize organ quality prior …

Mesenchymal stem cells (MSCs) modulate immune responses and maintain self-tolerance.
Their trophic activities and regenerative properties make them potential …

Abstract Background Mesenchymal stem cells (MSCs) have to be expanded in vitro to reach
a sufficient cell dose for the treatment of various diseases. During the process of expansion …

Normothermic machine perfusion (NMP) of injured kidneys offers the opportunity for
interventions to metabolically active organs prior to transplantation. Mesenchymal stromal …

Although solid organ transplantation remains the definitive management for patients with
end-stage organ failure, this ultimate treatment has been limited by the number of …

Pretransplant normothermic machine perfusion (NMP) of donor kidneys offers the unique
opportunity to perform active interventions to an isolated renal graft before transplantation …