A quinquennial review on recent advancements and developments in search of anti-malarial agents

TM Dhameliya, D Kathuria, TM Patel… - Current Topics in …, 2023 - benthamdirect.com
Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Application of liposomes in the treatment of infectious diseases

NAA Suhaimi, S Ahmad, SMN Husna, ME Sarmiento… - Life Sciences, 2022 - Elsevier
The advances in the development of drugs and vaccines for major infectious diseases of
tuberculosis (TB), malaria and HIV represent some of the most significant milestones in their …

Antiprotozoal drugs: challenges and opportunities

CT Supuran - Expert Opinion on Therapeutic Patents, 2023 - Taylor & Francis
Protozoans are widespread organisms in most habitats worldwide, being a paraphyletic
group with an intricate evolutionary history [1, 2]. There is a multitude of phyla, genera, and …

Boromycin has Rapid-Onset Antibiotic Activity Against Asexual and Sexual Blood Stages of Plasmodium falciparum

LP de Carvalho, S Groeger-Otero… - Frontiers in Cellular …, 2022 - frontiersin.org
Boromycin is a boron-containing macrolide antibiotic produced by Streptomyces antibioticus
with potent activity against certain viruses, Gram-positive bacteria and protozoan parasites …

Development of Curcumin nanophytosomes surface functionalized with Chondroitin sulfate-A for treating k1 Plasmodium falciparum drug-resistant malaria

E Bhargav, KB Koteshwara, YP Reddy… - Journal of Drug Delivery …, 2023 - Elsevier
The present study aimed to enhance the efficacy of Curcumin (CR) by a nanophytosomal
based drug delivery system. The DSPE-PEG-CSA lipid-polymer was synthesized and its …

Understanding the Antiplasmodial Action of Resistance-Refractory Xanthoquinodin A1

JE Collins, T Jiang, JW Lee, K Wendt… - ACS Infectious …, 2024 - ACS Publications
Our previous work identified a series of 12 xanthoquinodin analogues and 2 emodin-
dianthrones with broad-spectrum activities against Trichomonas vaginalis, Mycoplasma …

Phytochemical evaluation of Ziziphus mucronata and Xysmalobium undulutum towards the discovery and development of anti-malarial drugs

MN Buthelezi, VG Tshililo, AP Kappo, MBC Simelane - Malaria Journal, 2024 - Springer
Background The development of resistance by Plasmodium falciparum is a burdening
hazard that continues to undermine the strides made to alleviate malaria. As such, there is …

Challenges and promises for obtaining new antiprotozoal drugs: what's going wrong?

AB Vermelho, M Mori, WA Donald… - … drug development and …, 2022 - Springer
Infections by protozoa can cause some of the most serious human diseases, particularly in
tropical regions. However, the number of available drugs used to treat such diseases tends …

[PDF][PDF] Repurposing of FDA approved drugs having structural similarity to artemisinin against PfDHFR-TS through molecular docking and molecular dynamics …

L Patowary, MS Borthakur, JH Zothantluanga… - Curr. Trends Pharm …, 2021 - dibru.ac.in
Background: Malaria is caused by five species of Plasmodium parasites. It is responsible for
causing more than 200 million people malaria positive and kills more than 400,000 people …

Synthetic account on indoles and their analogues as potential anti-plasmodial agents

TM Dhameliya, DD Vekariya, PR Bhatt, T Kachroo… - Molecular Diversity, 2024 - Springer
Malaria caused by P. falciparum, has been recognized as one of the major infectious
diseases causing the death of several patients as per the reports from the World Health …