Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Vascular endothelial growth factor in eye disease

JS Penn, A Madan, RB Caldwell, M Bartoli… - Progress in retinal and …, 2008 - Elsevier
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Molecular pathology of age-related macular degeneration

X Ding, M Patel, CC Chan - Progress in retinal and eye research, 2009 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …

Macular degeneration: recent advances and therapeutic opportunities

A Rattner, J Nathans - Nature Reviews Neuroscience, 2006 - nature.com
The central retina mediates high acuity vision, and its progressive dysfunction due to
macular degeneration is the leading cause of visual disability among adults in industrialized …

Triple therapy for choroidal neovascularization due to age-related macular degeneration: verteporfin PDT, bevacizumab, and dexamethasone

AJ Augustin, S Puls, I Offermann - Retina, 2007 - journals.lww.com
Purpose: To evaluate the efficacy and safety of triple therapy with verteporfin photodynamic
therapy (PDT), dexamethasone, and bevacizumab in choroidal neovascularization (CNV) …

Immunopathological aspects of age-related macular degeneration

M Patel, CC Chan - Seminars in immunopathology, 2008 - Springer
Age-related macular degeneration (AMD) represents a leading cause of blindness
worldwide. While the clinical and histopathological aspects of AMD are well characterized …

[HTML][HTML] The protective effect of quercetin against oxidative stress in the human RPE in vitro

D Kook, AH Wolf, LY Alice, AS Neubauer… - … & visual science, 2008 - arvojournals.org
purpose. To investigate the possible protective effect of the dietary antioxidant quercetin on
retinal pigment epithelial (RPE) cell dysfunction and cellular senescence occurring in age …

Inflammation and age-related macular degeneration (AMD)

DG Telander - Seminars in ophthalmology, 2011 - Taylor & Francis
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly.
The cause of AMD is complex and many risk factors have been implicated including age …

Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration

K Morohoshi, AM Goodwin, M Ohbayashi… - Journal of autoimmunity, 2009 - Elsevier
Autoantibody production is associated with a variety of ocular disorders, including
autoimmune retinopathy (AIR) and age-related macular degeneration (AMD). A breakdown …

Interleukin gene polymorphisms in age-related macular degeneration

YY Tsai, JM Lin, L Wan, HJ Lin, Y Tsai… - … & visual science, 2008 - iovs.arvojournals.org
purpose. To investigate polymorphisms in a candidate gene of interleukin (IL) in unrelated
Taiwan Chinese patients with late age-related macular degeneration (AMD) and control …