The purine nucleoside adenosine is identified as a ubiquitous molecule regulator of different
tissues and cell functions. 1 Adenosine is generated in the extracellular space by the …

Drugs targeting adenosine receptors (AR) can provide treatment for diseases. We report the
identification of 7-(phenylamino)-pyrazolo [3, 4-c] pyridines L2–L10, A15, and A17 as low …

Adenosine was defined as a neuromodulator which exerts its action by interaction with
specific G-protein coupled receptor termed adenosine receptors. Adenosine receptors are …

CORAL software has been used to build quantitative structure–activity relationships
(QSARs) for the prediction of binding affinities (pEC50, ie, minus decimal logarithm of the …

Abstract A 2B adenosine receptors (A 2B ARs) are in the focus of interest as drug targets in
(immuno) oncology since antagonists show anti-proliferative, anti-angiogenic, anti …

Here we describe the design and synthesis of pyrazolo [3, 4-d] pyridazines as adenosine
receptor (AR) ligands. We demonstrate that the introduction of a 3-phenyl group, together …

Adenosine receptors (ARs) are ubiquitously distributed throughout the mammalian body
where they are involved in an extensive list of physiological and pathological processes that …

Selective adenosine receptor modulators are potential tools for numerous therapeutic
applications, including cardiovascular, inflammatory, and neurodegenerative diseases. In …

The interaction of 278 monocyclic and bicyclic pyrimidine derivatives with human A 2A
adenosine receptor (AR) was investigated by employing molecular dynamics …

An elegant solid-phase synthetic route of pyrazolo [3, 4-d] pyrimidine derivatives via Aza-
Wittig/electrocyclic ring closure reaction was developed and validated. By manipulating the …