Technological advances are continuously revealing new genetic variants that are often
difficult to interpret. As one of the most genetically tractable model organisms, yeast can …

Familial colorectal cancer type X (FCCTX) is a heterogeneous colorectal cancer
predisposition syndrome that, although displays a cancer pattern similar to Lynch syndrome …

Cervical cancer (CaCx) is the deadliest malignancy among women which is caused by
human papillomavirus (HPV) and anthro-demographical/clinicopathological factors. HPV …

Simple Summary A significant proportion of families with a clinical suggestion of Lynch
syndrome and screened for the known MMR genes remain without a molecular diagnosis …

Background Carriers of mutations in hereditary cancer predisposition genes represent a
small but clinically important subgroup of oncology patients. The identification of causal …

Head and neck cancer (HNC), the sixth most common cancer globally, stands second in
India. In Northeast (NE) India, it is the sixth most common cause of death in males and …

In this study, we determined if BRCA1 partners involved in DNA double-strand break (DSB)
and mismatch repair (MMR) may contribute to breast and ovarian cancer development …

Human kinases play essential and diverse roles in the cellular activities of maintaining
homeostasis and growth. Genetic mutations in the genes encoding the kinases (or …

Head and neck cancer (HNC), the sixth most common cancer globally, stands first in India,
especially Northeast India, where tobacco usage is predominant, which introduces various …

Activation-induced deaminase (AID) is required for somatic hypermutation in
immunoglobulin genes, but also induces off-target mutations. Follicular lymphoma (FL) and …