Runs of homozygosity: windows into population history and trait architecture

FC Ceballos, PK Joshi, DW Clark, M Ramsay… - Nature Reviews …, 2018 - nature.com
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each
parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding …

Determinants of genetic diversity

H Ellegren, N Galtier - Nature Reviews Genetics, 2016 - nature.com
Genetic polymorphism varies among species and within genomes, and has important
implications for the evolution and conservation of species. The determinants of this variation …

Accurate detection of identity-by-descent segments in human ancient DNA

H Ringbauer, Y Huang, A Akbari, S Mallick, I Olalde… - Nature Genetics, 2024 - nature.com
Long DNA segments shared between two individuals, known as identity-by-descent (IBD),
reveal recent genealogical connections. Here we introduce ancIBD, a method for identifying …

[HTML][HTML] Population genomics of post-glacial western Eurasia

ME Allentoft, M Sikora, A Refoyo-Martínez… - Nature, 2024 - nature.com
Western Eurasia witnessed several large-scale human migrations during the Holocene,,,–.
Here, to investigate the cross-continental effects of these migrations, we shotgun-sequenced …

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

P Wainschtein, D Jain, Z Zheng, LA Cupples… - Nature …, 2022 - nature.com
Analyses of data from genome-wide association studies on unrelated individuals have
shown that, for human traits and diseases, approximately one-third to two-thirds of …

[图书][B] Who we are and how we got here: Ancient DNA and the new science of the human past

D Reich - 2018 - books.google.com
The past few years have witnessed a revolution in our ability to obtain DNA from ancient
humans. This important new data has added to our knowledge from archaeology and …

Reference-based phasing using the Haplotype Reference Consortium panel

PR Loh, P Danecek, PF Palamara, C Fuchsberger… - Nature …, 2016 - nature.com
Haplotype phasing is a fundamental problem in medical and population genetics. Phasing is
generally performed via statistical phasing in a genotyped cohort, an approach that can yield …

Recent demographic history inferred by high-resolution analysis of linkage disequilibrium

E Santiago, I Novo, AF Pardiñas… - Molecular Biology …, 2020 - academic.oup.com
Inferring changes in effective population size (N e) in the recent past is of special interest for
conservation of endangered species and for human history research. Current methods for …

The ecological and genomic basis of explosive adaptive radiation

MD McGee, SR Borstein, JI Meier, DA Marques… - Nature, 2020 - nature.com
Speciation rates vary considerably among lineages, and our understanding of what drives
the rapid succession of speciation events within young adaptive radiations remains …

Ancient genomes show social and reproductive behavior of early Upper Paleolithic foragers

M Sikora, A Seguin-Orlando, VC Sousa, A Albrechtsen… - Science, 2017 - science.org
Present-day hunter-gatherers (HGs) live in multilevel social groups essential to sustain a
population structure characterized by limited levels of within-band relatedness and …