Arachidonic acid (AA), an n‐6 essential fatty acid, is a major component of mammalian cells
and can be released by phospholipase A2. Accumulating evidence indicates that AA plays …

Initial research on vitamin E and cancer has focused on α-tocopherol (αT), but recent clinical
studies on cancer-preventive effects of αT supplementation have shown disappointing …

Background Human tissues perform diverse metabolic functions. Mapping out these tissue-
specific functions in genome-scale models will advance our understanding of the metabolic …

Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the
oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA) …

The metabolism of arachidonic acid through lipoxygenase pathways leads to the generation
of various biologically active eicosanoids. The expression of these enzymes vary throughout …

Herein, we describe a solvent-and metal-free method for the synthesis of 3-chalcogenyl-
indoles from indoles and diorganyl dichalcogenides using an equivalent amount of DMSO …

Abstract The 4-substituted 1, 2, 3-triazole core in designed coumarin hybrids (4–35) with
diverse physicochemical properties was introduced by eco-friendly copper (I)-catalyzed …

Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …

ETHNOPHARMACOLOGICAL RELEVANCE: Terminalia chebula has an esteemed origin in
Indian mythology; its fruits are used to treat many diseases such as digestive, diabetes, colic …

Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs;
however, the results from human trials are mixed, making it difficult to provide dietary …