Motivation A large number of protein sequences are becoming available through the
application of novel high-throughput sequencing technologies. Experimental functional …

The analysis of protein-protein interactions is fundamental to the understanding of cellular
organization, processes, and functions. Recent large-scale investigations of protein-protein …

The assignment of function to proteins at a large scale is essential for understanding the
molecular mechanism of life. However, only a very small percentage of the more than 179 …

Proteomics is the extensive investigation of proteins which has empowered the recognizable
proof of consistently expanding quantities of protein. Proteins are necessary part of living life …

Genome-wide linkage and association studies have demonstrated promise in identifying
genetic factors that influence health and disease. An important challenge is to narrow down …

During the genomic revolution, algorithmic and analytical methods for organizing,
integrating, analyzing, and querying biological sequence data proved invaluable. Today …

Knowledge of protein functions plays an important role in biology and medicine. With the
rapid development of high-throughput technologies, a huge number of proteins have been …

Predicting protein function from protein interaction networks has been challenging because
of the complexity of functional relationships among proteins. Most previous function …

The recent advent of high-throughput methods has generated large amounts of gene
interaction data. This has allowed the construction of genomewide networks. A significant …

Assigning biological functions to uncharacterized proteins is a fundamental problem in the
postgenomic era. The increasing availability of large amounts of data on protein-protein …