Cross‐Coupling of Heteroarenes by C H Functionalization: Recent Progress towards Direct Arylation and Heteroarylation Reactions Involving Heteroarenes …
In recent years, transition metal‐catalyzed direct (hetero) arylation reactions of heteroarenes
with (hetero) aryl halides and pseudohalides have received significant attention as eco …
with (hetero) aryl halides and pseudohalides have received significant attention as eco …
Antituberculosis drugs: ten years of research
YL Janin - Bioorganic & medicinal chemistry, 2007 - Elsevier
Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …
Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis
A Lilienkampf, J Mao, B Wan, Y Wang… - Journal of medicinal …, 2009 - ACS Publications
Tuberculosis (TB) remains as a global pandemic that is aggravated by a lack of health care,
the spread of HIV, and the emergence of multidrug-resistant TB (MDR-TB) and extensively …
the spread of HIV, and the emergence of multidrug-resistant TB (MDR-TB) and extensively …
Targeting Phenotypically Tolerant Mycobacterium tuberculosis
Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …
was a revolution in medicine as physicians went to war with microbes. The second was a …
[HTML][HTML] Targeting the ATP synthase in bacterial and fungal pathogens: beyond Mycobacterium tuberculosis
M Vestergaard, D Bald, H Ingmer - Journal of Global Antimicrobial …, 2022 - Elsevier
The ATP synthase is a multicomponent enzyme that is largely conserved across the
kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by …
kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by …
Oxidative phosphorylation as a target space for tuberculosis: success, caution, and future directions
The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …
adapted to inhabit a wide range of intracellular and extracellular environments …
Viridans Group Streptococci Are Donors in Horizontal Transfer of Topoisomerase IV Genes to Streptococcus pneumoniae
L Balsalobre, MJ Ferrándiz, J Linares… - Antimicrobial agents …, 2003 - Am Soc Microbiol
ABSTRACT A total of 46 ciprofloxacin-resistant (Cipr) Streptococcus pneumoniae strains
were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed …
were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed …
Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease
CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …
their potential against several of the world's most important neglected tropical diseases …
Variations of Subunit ε of the Mycobacterium tuberculosis F1Fo ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207
G Biuković, S Basak, MSS Manimekalai… - Antimicrobial agents …, 2013 - Am Soc Microbiol
The subunit ε of bacterial F1FO ATP synthases plays an important regulatory role in coupling
and catalysis via conformational transitions of its C-terminal domain. Here we present the …
and catalysis via conformational transitions of its C-terminal domain. Here we present the …
Structure of ATP synthase from ESKAPE pathogen Acinetobacter baumannii
The global spread of multidrug-resistant Acinetobacter baumannii infections urgently calls
for the identification of novel drug targets. We solved the electron cryo-microscopy structure …
for the identification of novel drug targets. We solved the electron cryo-microscopy structure …