Contrary to Warburg's original thesis, accelerated aerobic glycolysis is not a primary,
permanent and universal consequence of dysfunctional or impaired mitochondria …

Organismal development requires the reproducible unfolding of an ordered sequence of
discrete steps (cell fate determination, migration, tissue folding, etc.) in both time and space …

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in
embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight …

Lipids are a potential reservoir of energy for initial embryonic development before activation
of the embryonic genome and are involved in plasma membrane biosynthesis. Excessive …

The mammalian blastocyst exhibits an idiosyncratic metabolism, reflecting its unique
physiology and its ability to undergo implantation. Glucose is the primary nutrient of the …

BACKGROUND Assisted reproduction technology offers the opportunity to observe the very
early stages of human development. However, due to practical constraints, for decades …

Environmental contributions to cancer development are widely accepted, but only a fraction
of all pertinent exposures have probably been identified. Traditional toxicological …

Well-orchestrated maternal–fetal cross talk occurs via secreted ligands, interacting
receptors, and coupled intracellular pathways between the conceptus and endometrium and …

Recent data suggest that most genotoxic agents in cancer therapy can lead to shock of
genome and increase in cell size, which leads whole genome duplication or multiplication …

Introduction Embryo and fetus grow and mature over the first trimester of pregnancy in a
dynamic hypoxic environment, where placenta development assures an increased oxygen …