Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations

DG Delafield, G Lu, CJ Kaminsky, L Li - TrAC Trends in Analytical …, 2022 - Elsevier
Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Ion mobility mass spectrometry for the separation and characterization of small molecules

L Liu, Z Wang, Q Zhang, Y Mei, L Li, H Liu… - Analytical …, 2023 - ACS Publications
Small molecules with molecular weights less than 1500 Da represented by natural
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …

Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective

ES Rivera, KV Djambazova… - Journal of Mass …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of
biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential …

Recent advances in biological separations using trapped ion mobility spectrometry–mass spectrometry

KJD Fouque, F Fernandez-Lima - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
Abstract Ion Mobility Spectrometry (IMS) is a widely used technique for the post-ionization
separation and structural characterization of biomolecules. Trapped IMS (TIMS) is a …

Substrate sequence controls regioselectivity of lanthionine formation by ProcM

T Le, K Jeanne Dit Fouque… - Journal of the …, 2021 - ACS Publications
Lanthipeptides belong to the family of ribosomally synthesized and post-translationally
modified peptides (RiPPs). The (methyl) lanthionine cross-links characteristic to …

Mass spectrometry analysis of drugs of abuse: challenges and emerging strategies

SA Borden, J Palaty, V Termopoli… - Mass spectrometry …, 2020 - Wiley Online Library
Mass spectrometry has been the “gold standard” for drugs of abuse (DoA) analysis for many
decades because of the selectivity and sensitivity it affords. Recent progress in all aspects of …

Multidimensional separations of intact phase II steroid metabolites utilizing LC–ion mobility–HRMS

DE Davis Jr, KL Leaptrot, DC Koomen, JC May… - Analytical …, 2021 - ACS Publications
The detection and unambiguous identification of anabolic-androgenic steroid metabolites
are essential in clinical, forensic, and antidoping analyses. Recently, sulfate phase II steroid …

Trends in trapped ion mobility–Mass spectrometry instrumentation

ME Ridgeway, C Bleiholder, M Mann… - TrAC Trends in Analytical …, 2019 - Elsevier
Abstract Trapped Ion Mobility Spectrometry (TIMS) is a recently developed form of ion
mobility spectrometry (IMS) which is flexible in its operation and readily hybridized with mass …

A high-throughput ion mobility spectrometry–mass spectrometry screening method for opioid profiling

KE Butler, ES Baker - Journal of the American Society for Mass …, 2022 - ACS Publications
In 2017, the United States Department of Health and Human Services declared the
widespread misuse and abuse of prescription and illicit opioids an epidemic. However, this …