In silico study of SARS‐CoV‐2 spike protein RBD and human ACE‐2 affinity dynamics across variants and Omicron subvariants

S Abeywardhana, M Premathilaka… - Journal of medical …, 2023 - Wiley Online Library
The coronavirus disease 2019 virus outbreak continues worldwide, with many variants
emerging, some of which are considered variants of concern (VOCs). The WHO designated …

PRKCE non-coding variants influence on transcription as well as translation of its gene

K Khan, S Zafar, A Hafeez, Y Badshah, K Shahid… - RNA biology, 2022 - Taylor & Francis
Untranslated regions of the gene play a crucial role in gene expression regulation at mRNA
and protein levels. Mutations at UTRs impact expression by altering transcription factor …

Characterization and expression profiling of fadd gene in response to exogenous Aeromonas hydrophila or Edwardsiella tarda challenge in the hybrid yellow catfish …

S Guo, M Zeng, L Chen, H Chen, W Gao… - Fish & Shellfish …, 2023 - Elsevier
In mammals, fas-associated protein with death domain (FADD) is involved in the process of
cell apoptosis and plays a key role in innate immune signaling. Nevertheless, its detailed …

[HTML][HTML] Network pharmacology analysis to explore mechanism of Three Flower Tea against nonalcoholic fatty liver disease with experimental support using high-fat …

P Wu, S Liang, Y He, R Lv, B Yang, M Wang… - Chinese herbal …, 2022 - Elsevier
Objective Nonalcoholic fatty liver disease (NAFLD) has become a common chronic liver
disease that is harmful to human health. Moreover, there is currently no FDA-approved first …

Light intensity–mediated auxin homeostasis in spikelets links carbohydrate metabolism enzymes with grain filling rate in rice

D Panda, S Mohanty, S Das, B Mishra, MJ Baig… - Protoplasma, 2023 - Springer
Low light (LL) stress during the grain-filling stage acutely impairs the quality and quantity of
starch accumulation in rice grains. Here, we observed that LL-induced poor starch …

Angiopoietin-1 derived peptide hydrogel promotes molecular hallmarks of regeneration and wound healing in dermal fibroblasts

K Vizely, KT Wagner, S Mandla, D Gustafson, JE Fish… - Iscience, 2023 - cell.com
By providing an ideal environment for healing, biomaterials can be designed to facilitate and
encourage wound regeneration. As the wound healing process is complex, there needs to …

Differentially expressed genes and enriched signaling pathways in the adipose tissue of obese people

Z Lu, L Meng, Z Sun, X Shi, W Shao, Y Zheng… - Frontiers in …, 2021 - frontiersin.org
As the prevalence of obesity increases, so does the occurrence of obesity-related
complications, such as cardiovascular and cerebrovascular diseases, diabetes, and some …

Physiologically based pharmacokinetic (PBPK) modeling to predict CYP3A-mediated drug interaction between saxagliptin and nicardipine: bridging rat-to-human …

JM Lee, JH Yoon, HJ Maeng, YC Kim - Pharmaceutics, 2024 - mdpi.com
The aim of this study was to predict the cytochrome P450 3A (CYP3A)-mediated drug–drug
interactions (DDIs) between saxagliptin and nicardipine using a physiologically based …

Interpolation and extrapolation in Year 5 STEM activities: exploring data about viscosity without advanced statistics

J Watson, N Fitzallen, B Kelly - Mathematics Education Research Journal, 2023 - Springer
Incorporating an evidence-based approach in STEM education using data collection and
analysis strategies when learning about science concepts enhances primary students' …

An inclusive study of deleterious missense PAX9 variants using user-friendly tools reveals structural, functional alterations, as well as potential therapeutic targets.

P Ranjan, P Das - International Journal of Biological Macromolecules, 2023 - Elsevier
Mutations in the PAX9 are responsible for non-syndromic tooth agenesis in humans,
although their structural and functional consequences on protein phenotype, stability, and …