All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

Approximately 20% of patients diagnosed with a phaeochromocytoma or paraganglioma
carry a germline mutation in one of the succinate dehydrogenase (SDHx) genes (SDHA …

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …

The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four
subunits: SDHA, SDHB, SDHC and SDHD. Remarkably, immunohistochemistry for SDHB …

Purpose Genetic factors have been implicated in the pathogenesis of renal cell carcinoma
(RCC), with around 3% of cases having a family history. A greater knowledge of the genetics …

Simple Summary Pheochromocytoma and paraganglioma (together PPGL) are rare
neuroendocrine tumors that arise from chromaffin tissue and produce catecholamines …

The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …

Substantial advances have been made recently in the pathobiology of pituitary tumors.
Similar to many other endocrine tumors, over the last few years we have recognized the role …

Clinically relevant pituitary adenomas are present in about 1 per 1,000 of the general
population and prolactinomas are by far the most common clinical subtype of pituitary …

This review of the familial tumor syndromes involving the endocrine organs is focused on
discussing the main updates on the upcoming fifth edition of the WHO Classification of …