The adaptive immune system and associated inflammation are vital in surveillance and host protection against internal and external threats, but can secondarily damage host tissues …
The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …
R Shechter, A London, M Schwartz - Nature Reviews Immunology, 2013 - nature.com
Complex barriers separate immune-privileged tissues from the circulation. Here, we propose that cell entry to immune-privileged sites through barriers composed of tight junction …
Most higher animals require sight for survival, yet even minor distortions of the visual axis can cause blindness. For this reason, intraocular inflammation is incompatible with good …
J Hori, T Yamaguchi, H Keino, P Hamrah… - Progress in retinal and …, 2019 - Elsevier
Corneal transplantation is the most successful solid organ transplantation performed in humans. The extraordinary success of orthotopic corneal allografts, in both humans and …
Immune-mediated inflammation and allograft rejection are greatly reduced in certain organs, a phenomenon called'immune privilege'. Immune privilege is well developed in three …
AW Taylor - Frontiers in immunology, 2016 - frontiersin.org
Allografts are afforded a level of protection from rejection within immune-privileged tissues. Immune-privileged tissues involve mechanisms that suppress inflammation and promote …
It has been over 60 years since the phrase immune privilege was used by Sir Peter Medawar to describe the lack of an immune response against allografts placed into the …
J Stein-Streilein, JW Streilein - International reviews of …, 2002 - Taylor & Francis
Immune privilege was first explored in the late 1800s by van Dooremaal, and was then extended by Medawar in the mid 1900s to fit in with emerging concepts of transplantation …