Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of
ion channels that contribute to Cell-Cell communication in the microcirculation. Endothelial …

This review is concerned with understanding how vasodilation initiated from local sites in the
tissue can spread to encompass multiple branches of the resistance vasculature. Within …

Endothelial cell (EC) Ca2+-activated K channels (SKCa and IKCa channels) generate
hyperpolarization that passes to the adjacent smooth muscle cells causing vasodilation …

Calcium (Ca2+) release through inositol 1, 4, 5-trisphosphate receptors (IP3Rs) regulates
the function of virtually every mammalian cell. Unlike ryanodine receptors, which generate …

Key points The endothelium plays a pivotal role in the vascular response to chemical and
mechanical stimuli. The endothelium is exquisitely sensitive to ACh, although the …

Arterial hyperpolarization to acetylcholine (ACh) reflects coactivation of KCa3. 1 (IKCa)
channels and KCa2. 3 (SKCa) channels in the endothelium that transfers through …