Intermediate filaments (IFs) are key players in multiple cellular processes throughout human
tissues. Their biochemical and structural properties are important for understanding filament …

Mechanotransduction translates forces into biological responses and regulates cell
functionalities. It is implicated in several diseases, including laminopathies which are …

The nuclear envelope separates the genome from the cytoplasmic environment. However,
the nuclear envelope is also physically associated with the genome and exerts influence on …

Hundreds of LMNA variants have been associated with several distinct disease phenotypes.
However, genotype–phenotype relationships remain largely undefined and the impact for …

Mechanotransduction, which is the integration of mechanical signals from the external
environment of a cell to changes in intracellular signaling, governs many cellular functions …

The nuclear lamina (NL) plays various roles and participates in nuclear integrity, chromatin
organization, and transcriptional regulation. Lamin proteins, the main components of the NL …

Lamins are nucleoskeletal proteins of mammalian cells that stabilize the structure and
maintain the rigidity of the nucleus. These type V intermediate filament proteins which are …

Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular
mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a …

The separation of genetic material from bulk cytoplasm has enabled the evolution of
increasingly complex organisms, allowing for the development of sophisticated forms of life …

Lamins form a proteinaceous meshwork as a major structural component of the nucleus.
Lamins, along with their interactors, act as determinants for chromatin organization …