Advances in the clinical application of ultrasound elastography in uterine imaging

X Wang, S Lin, G Lyu - Insights into Imaging, 2022 - Springer
Abstract Changes in tissue stiffness by physiological or pathological factors in tissue
structure are identified earlier than their clinical features. Pathological processes such as …

Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease

EJ Zaniker, M Zhang, L Hughes… - Biology of …, 2024 - academic.oup.com
The ovary is one of the first organs to show overt signs of aging in the human body, and
ovarian aging is associated with a loss of gamete quality and quantity. The age-dependent …

Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

JS Gnecco, A Brown, K Buttrey, C Ives, BA Goods… - Med, 2023 - cell.com
Background The human endometrium undergoes recurring cycles of growth, differentiation,
and breakdown in response to sex hormones. Dysregulation of epithelial-stromal …

Material properties of nonpregnant and pregnant human uterine layers

DM Fodera, SR Russell, JLL Jackson, S Fang… - Journal of the …, 2024 - Elsevier
The uterus has critical biomechanical functions in pregnancy and undergoes dramatic
material growth and remodeling from implantation to parturition. The intrinsic material …

Three-dimensional anisotropic hyperelastic constitutive model describing the mechanical response of human and mouse cervix

L Shi, L Hu, N Lee, S Fang, K Myers - Acta Biomaterialia, 2022 - Elsevier
The mechanical function of the uterine cervix is critical for a healthy pregnancy. During
pregnancy, the cervix undergoes significant softening to allow for a successful delivery …

Multiphysics and multiscale modeling of uterine contractions: integrating electrical dynamics and soft tissue deformation with fiber orientation

A Ballit, TT Dao - Medical & Biological Engineering & Computing, 2024 - Springer
The development of a comprehensive uterine model that seamlessly integrates the intricate
interactions between the electrical and mechanical aspects of uterine activity could …

Stiff Extracellular Matrix Promotes Invasive Behaviors of Trophoblast Cells

J Cao, H Li, H Tang, X Gu, Y Wang, D Guan, J Du… - Bioengineering, 2023 - mdpi.com
The effect of extracellular matrix (ECM) stiffness on embryonic trophoblast cells invasion
during mammalian embryo implantation remains largely unknown. In this study, we …

A finite porous-viscoelastic model capturing mechanical behavior of human cervix under multi-step spherical indentation

L Shi, K Myers - Journal of the Mechanical Behavior of Biomedical …, 2023 - Elsevier
The cervix is a soft tissue exhibiting time-dependent behavior under mechanical loads. The
cervix is a vital mechanical barrier to protect the growing fetus. The remodeling of the …

Beyond 2D: Novel biomaterial approaches for modeling the placenta

SG Zambuto, AK Scott, ML Oyen - Placenta, 2024 - Elsevier
This review considers fully three-dimensional biomaterial environments of varying
complexity as these pertain to research on the placenta. The developments in placental cell …

Equilibrium mechanical properties of the human uterus in tension and compression

S Fang, CA Duarte, DM Fodera, L Shi, X Chen… - Acta Biomaterialia, 2025 - Elsevier
A successful pregnancy relies on the proper cellular, biochemical, and mechanical functions
of the uterus. A comprehensive understanding of nonpregnant and pregnant uterine …