The biochemical processes leading to the synthesis of new proteins are random, as they
typically involve a small number of diffusing molecules. They lead to fluctuations in the …

Transcription of highly expressed genes has been shown to occur in stochastic bursts. But
the origin of such ubiquitous phenomenon has not been understood. Here, we present the …

Gene activity is described by the time series of discrete, stochastic mRNA production events.
This transcriptional time series shows intermittent, bursty behavior. One consequence of this …

Variability in gene expression among genetically identical cells has emerged as a central
preoccupation in the study of gene regulation; however, a divide exists between the …

The expression level of a gene can fluctuate significantly between individuals within a
population of genetically identical cells. The resultant phenotypic heterogeneity could be …

Cells in isogenic populations may differ substantially in their molecular make up because of
the stochastic nature of molecular processes. Stochastic bursts in process activity have a …

Gene expression is a complicated multistep process where transcription depends on a
chromatin template that can be characterized by stochastic transitions between active and …

A bacterial disease was reported from gilthead sea bream (Sparus aurata) within a hatchery
environment in Malta. Symptoms included complete erosion of tail, infection in the eye …

Abstract The pathogen Mycobacterium tuberculosis (Mtb), the causative agent of
tuberculosis, enacts unique transcriptional regulatory mechanisms when subjected to host …

Deciphering how the regulatory DNA sequence of a gene dictates its expression in
response to intra and extracellular cues is one of the leading challenges in modern …