To understand the placement of a certain protein in a physiological system and the
pathogenesis of related disorders, it is not only of interest to determine its function but also …

Abstract von Willebrand factor (vWF) was first identified as an adhesive glycoprotein
involved in hemostasis by Zimmermann in 1971. Since then, vWF has been shown to play a …

Vascular endothelial cells contain unique storage organelles, designated Weibel-Palade
bodies (WPBs), that deliver inflammatory and hemostatic mediators to the vascular lumen in …

Von Willebrand disease (VWD) is a bleeding disorder that is mainly caused by mutations in
the multimeric protein von Willebrand factor (VWF). These mutations may lead to …

Von Willebrand disease (VWD) is a heterogeneous bleeding disorder caused by decrease
or dysfunction of von Willebrand factor (VWF). A wide range of mutations in the VWF gene …

Patients with von Willebrand disease (VWD) are often heterozygous for a missense mutation
in the von Willebrand factor (VWF) gene. Investigating the pathogenic features of VWF …

Von Willebrand factor (VWF), a key player in hemostasis, is increasingly recognized as a
proinflammatory protein. Here, we found a massive accumulation of VWF in skin biopsies of …

Summary Weibel–Palade bodies (WPBs) are the storage organelles for von Willebrand
factor (VWF) in endothelial cells. VWF forms multimers that assemble into tubular structures …

Multimeric von Willebrand factor (VWF) is essential for primary hemostasis. The biosynthesis
of VWF high-molecular-weight multimers requires spatial separation of each step because of …

Endothelial cells deliver a vital contribution to the maintenance of hemostasis by constituting
an anatomical as well as functional barrier between the blood and the rest of the body. Apart …