Blood vessels and nerve fibers are distributed throughout the entirety of skeletal tissue, and
play important roles during bone development and fracture healing by supplying oxygen …

Abstract Purpose of Review This review examines the diverse functional relationships that
exist between the peripheral nervous system (PNS) and bone, including key advances over …

Critical-sized bone defects remain an unsolved challenge because of the failure to induce
early reconstruction of the neuro-vascularization network. Nerve and vascular regeneration …

Craniofacial tissue injuries, diseases, and defects, including those within bone, dental, and
periodontal tissues and salivary glands, impact an estimated 1 billion patients globally …

Despite progress in bone tissue engineering, reconstruction of large bone defects remains
an important clinical challenge. Here, a biomaterial designed to recruit bone cells …

Neuropeptide Y (NPY) is a neuropeptide secreted by sensory nerve fibers distributed in the
marrow and vascular canals of bone tissue. However, the effect of NPY on the osteogenic …

Background Tissue-engineered bone grafts (TEBGs) that undergo vascularization and
neurotization evolve into functioning bone tissue. Previously, we verified that implanting …

Bilateral communication between bone and nerves is crucial for optimal repair of large bone
defects as well as repair of peripheral nerves within the skeleton. However, simultaneous …

Background: Calcitonin gene-related peptide (CGRP) is a neuropeptide distributed in bone
tissue involved in bone remodeling. Previously we demonstrated that CGRP can promote …

Our previous work showed that implanting a sensory nerve or vascular bundle when
constructing vascularized and neurotized bone could promote bone osteogenesis in tissue …