Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Understanding the function of biological macromolecules and their complexes at the
physicochemical level requires knowledge of both their structure and dynamics …

Myriad biological processes proceed through states that defy characterization by
conventional atomic-resolution structural biological methods. The invisibility of these …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

The use of 1H transverse paramagnetic relaxation enhancement (PRE) has seen a
resurgence in recent years as method for providing long-range distance information for …

Seven-helix membrane proteins represent a challenge for structural biology. Here we report
the first NMR structure determination of a detergent-solubilized seven-helix transmembrane …

Natively unfolded proteins present a challenge for structure determination because they
populate highly heterogeneous ensembles of conformations. A useful source of structural …

Coronavirus envelope (CoV E) proteins are∼ 100-residue polypeptides with at least one
channel-forming α-helical transmembrane (TM) domain. The extramembrane C-terminal tail …

Solution NMR spectroscopy represents a powerful tool for examining the structure and
function of biological macromolecules. The advent of multidimensional (2D-4D) NMR …

Recent advances in the use of paramagnetic relaxation enhancement (PRE) in structure
refinement and in the analysis of transient dynamic processes involved in macromolecular …