Recent advances in local drug delivery to the inner ear

N El Kechai, F Agnely, E Mamelle, Y Nguyen… - International journal of …, 2015 - Elsevier
Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …

Which medication do I need to manage dizzy patients?

D Huppert, M Strupp, H Mückter, T Brandt - Acta oto-laryngologica, 2011 - Taylor & Francis
Vertigo and dizziness are not independent disease entities, but instead symptoms of various
diseases. Accordingly, a variety of treatment approaches are required. Here we review the …

Long-term outcomes of triple semicircular canal plugging for the treatment of intractable Meniere's disease: A single center experience of 361 cases

D Zhang, Y Lv, Y Han, Y Li, X Li, J Wang… - Journal of vestibular …, 2019 - content.iospress.com
METHODS: Three hundred and sixty-one unilateral MD patients, who were treated with
TSCP in our hospital between Dec. 2010 and Sep. 2016, were recruited in this study for …

Intratympanic gentamicin for intractable Meniere's Disease–a review and analysis of audiovestibular impact

S Yetişer - International Archives of Otorhinolaryngology, 2018 - thieme-connect.com
Introduction Intratympanic gentamicin regulates the symptoms in most patients with
incapacitating Ménière's disease. The treatment protocols have changed over the years from …

New insights into aminoglycoside antibiotics and derivatives

JG Silva, I Carvalho - Current medicinal chemistry, 2007 - ingentaconnect.com
In the post-genome era, RNA has emerged as a valid molecular target involved in many
biochemical pathways such as cellular protein interactions. This includes transcription and …

Long-term efficacy of triple semicircular canal plugging in the treatment of patients with ipsilateral delayed endolymphatic hydrops

D Zhang, Y Lv, X Li, Y Li, Y Song, Z Fan, H Wang - Scientific Reports, 2021 - nature.com
This study aims to explore the long-term efficacy of triple semicircular canal plugging (TSCP)
in the treatment of intractable ipsilateral delayed endolymphatic hydrops (DEH), so as to …

Gadolinium uptake in the rat inner ear perilymph evaluated with 4.7 T MRI: a comparison between transtympanic injection and gelatin sponge-based diffusion through …

J Zou, UA Ramadan, I Pyykkö - Otology & Neurotology, 2010 - journals.lww.com
Objective: To investigate the inner ear uptake of the contrast agent gadolinium administered
intratympanically through transtympanic injection or using a gelatin sponge placed on the …

Intratympanic gentamicin in Ménière's disease: our experience

LP Delgado, JF Rodrigo, PA Peña - The Journal of Laryngology & …, 2011 - cambridge.org
Aims: To analyse intratympanic gentamicin injection as a treatment option in patients with
monolateral Ménière's disease resistant to medical treatment. Material and methods …

Intratympanic injection in Meniere's disease; symptomatic and audiovestibular; comparative, prospective randomized 1-year control study

YF ElBeltagy, AG Shafik, AM Mahmoud… - The Egyptian Journal of …, 2012 - Springer
En Abstract Objective The aim of this work is to compare the effectiveness of intratympanic
therapy of gentamicin versus steroids in the treatment of Meniere's disease in terms of …

Contemporary role of endolymphatic mastoid shunt surgery in the era of transtympanic perfusion strategies

L Lee, ML Pensak - Annals of Otology, Rhinology & …, 2008 - journals.sagepub.com
Objectives: Although there exist undisputed methods to permanently silence the aberrant
end organ, controversy surrounds the durable efficacy of non-ablative interventions. This …