[HTML][HTML] FDA-approved oximes and their significance in medicinal chemistry
Despite the scientific advancements, organophosphate (OP) poisoning continues to be a
major threat to humans, accounting for nearly one million poisoning cases every year …
major threat to humans, accounting for nearly one million poisoning cases every year …
An insight into the advanced synthetic recipes to access ubiquitous indole heterocycles
Indoles are amongst the most essential class of heteroaromatics in organic chemistry, being
commonly found in biologically active natural products. Indole and its derivatives have …
commonly found in biologically active natural products. Indole and its derivatives have …
[HTML][HTML] Synthesis, in silico analysis, and biomedical effects of coumarins derived from resveratrol
YF Mustafa - Phytomedicine plus, 2023 - Elsevier
Background Resveratrol (RVL) is a polyphenol-containing natural product found in a variety
of plants, including peanuts, grapes, and berry fruits. The use of RVL is linked in a great deal …
of plants, including peanuts, grapes, and berry fruits. The use of RVL is linked in a great deal …
Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents
Staphylococcus aureus is a fatal Gram-positive pathogen threatening numerous cases of
hospital-admitted patients worldwide. The emerging resistance of the pathogen to several …
hospital-admitted patients worldwide. The emerging resistance of the pathogen to several …
Vanillin-based indolin-2-one derivative bearing a pyridyl moiety as a promising anti-breast cancer agent via anti-estrogenic activity
The structure-based design introduced indoles as an essential motif in designing new
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …
selective estrogen receptor modulators employed for treating breast cancer. Therefore, here …
An insight into the recent developments in anti-infective potential of indole and associated hybrids
BS Mathada, SB Somappa - Journal of Molecular Structure, 2022 - Elsevier
Prevention, accurate diagnosis, and effective treatment of infections are the main challenges
in the overall management of infectious diseases. The best example is the ongoing SARs …
in the overall management of infectious diseases. The best example is the ongoing SARs …
Computer-aided discovery of bis-indole derivatives as multi-target drugs against cancer and bacterial infections: DFT, docking, virtual screening, and molecular …
Recently, more complex diseases of seemingly incurable pathology have demonstrated the
need for potent and multi-target drugs. Specific to many cancers and bacterial diseases …
need for potent and multi-target drugs. Specific to many cancers and bacterial diseases …
Rhodium(III)-Catalyzed Dehydrogenative Annulation and Spirocyclization of 2-Arylindoles and 2-(1H-Pyrazol-1-yl)-1H-indoles with Maleimides: A Facile Access to …
A Rh (III)-catalyzed dehydrogenative annulation and spirocyclization of 2-arylindoles and 2-
(1 H-pyrazol-1-yl)-1 H-indole with maleimides is described. The cascade protocol provided …
(1 H-pyrazol-1-yl)-1 H-indole with maleimides is described. The cascade protocol provided …
Targeting cell signaling pathways in lung cancer by bioactive phytocompounds
Simple Summary Lung cancer is the leading cause of mortality in cancer patients, causing
an estimated 1.8 million deaths in the year 2020. However, the available therapeutic options …
an estimated 1.8 million deaths in the year 2020. However, the available therapeutic options …
Revisiting the inhibitory potential of protein kinase inhibitors against NEK7 protein via comprehensive computational investigations
The NEK7 protein is required for spindle formation, cell division, and the activation of the
NLRP3 inflammasome receptor. The aberrant expression of NEK7 has been implicated to …
NLRP3 inflammasome receptor. The aberrant expression of NEK7 has been implicated to …