Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

MR Kudelka, SR Stowell, RD Cummings… - Nature reviews …, 2020 - nature.com
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

A randomized trial comparing the specific carbohydrate diet to a Mediterranean diet in adults with Crohn's disease

JD Lewis, RS Sandler, C Brotherton, C Brensinger, H Li… - Gastroenterology, 2021 - Elsevier
Background & Aims This study compared the effectiveness of the Specific Carbohydrate Diet
(SCD) to the Mediterranean diet (MD) as treatment for Crohn's disease (CD) with mild to …

The Crohn's disease exclusion diet for induction and maintenance of remission in adults with mild-to-moderate Crohn's disease (CDED-AD): an open-label, pilot …

H Yanai, A Levine, A Hirsch, RS Boneh… - The Lancet …, 2022 - thelancet.com
Summary Background The Crohn's disease exclusion diet (CDED) with partial enteral
nutrition is effective for induction of remission in children with mild-to-moderate Crohn's …

Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases

A Levine, RS Boneh, E Wine - Gut, 2018 - gut.bmj.com
Recent advances in basic and clinical science over the last 3 years have dramatically
altered our appreciation of the role of diet in inflammatory bowel diseases (IBD). The marked …

Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's disease

JD Lewis, EZ Chen, RN Baldassano, AR Otley… - Cell host & …, 2015 - cell.com
Abnormal composition of intestinal bacteria—" dysbiosis"—is characteristic of Crohn's
disease. Disease treatments include dietary changes and immunosuppressive anti-TNFα …

Diet as a trigger or therapy for inflammatory bowel diseases

JD Lewis, MT Abreu - Gastroenterology, 2017 - Elsevier
The most common question asked by patients with inflammatory bowel disease (IBD)
is,“Doctor, what should I eat?” Findings from epidemiology studies have indicated that diets …

Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts

TE Adolph, J Zhang - Gut, 2022 - gut.bmj.com
The diet and gut microbiota have been extensively interrogated as a fuel for gut
inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review …

Systematic review with meta‐analysis: mucosal healing is associated with improved long‐term outcomes in Crohn's disease

SC Shah, JF Colombel, BE Sands… - Alimentary …, 2016 - Wiley Online Library
Summary Background Clinical manifestations of Crohn's disease (CD) do not reliably
correlate with endoscopic activity. While treating to achieve clinical remission (CR) has …

The microbiota in inflammatory bowel disease: current and therapeutic insights

ER Lane, TL Zisman, DL Suskind - Journal of inflammation …, 2017 - Taylor & Francis
Inflammatory bowel disease is a heterogeneous group of chronic disorders that result from
the interaction of the intestinal immune system with the gut microbiome. Until recently, most …