MHC class I downregulation in cancer: underlying mechanisms and potential targets for cancer immunotherapy

AM Cornel, IL Mimpen, S Nierkens - Cancers, 2020 - mdpi.com
In recent years, major advances have been made in cancer immunotherapy. This has led to
significant improvement in prognosis of cancer patients, especially in the hematological …

Natural compounds and combination therapy in colorectal cancer treatment

A Rejhová, A Opattová, A Čumová, D Slíva… - European journal of …, 2018 - Elsevier
Colorectal cancer (CRC) therapy using conventional chemotherapeutics represents a
considerable burden for the patient's organism because of high toxicity while the response is …

Betulin and betulinic acid: Triterpenoids derivatives with a powerful biological potential

A Hordyjewska, A Ostapiuk, A Horecka… - Phytochemistry …, 2019 - Springer
Betulin, a pentacyclic triterpene and a plant pentacyclic triterpene metabolite, can be found
in large quantities in the outer bark of the birches (Betula, Betulaceae). Betulinic acid …

Natural products: an evolving role in future drug discovery

BB Mishra, VK Tiwari - European journal of medicinal chemistry, 2011 - Elsevier
The therapeutic areas of infectious diseases and oncology have benefited from abundant
scaffold diversity in natural products, able to interact with many specific targets within the cell …

Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications

B Singh, RA Sharma - 3 Biotech, 2015 - Springer
The terpenoids constitute the largest class of natural products and many interesting products
are extensively applied in the industrial sector as flavors, fragrances, spices and are also …

Pharmacological activities of natural triterpenoids and their therapeutic implications

P Dzubak, M Hajduch, D Vydra, A Hustova… - Natural product …, 2006 - pubs.rsc.org
Covering: 1990–2005. Previous review: Nat. Prod. Rep., 2005, 22, 487 This article reviews
the pharmacological activity of naturally occurring triterpenoids excluding the degraded …

Pharmacological properties of the ubiquitous natural product betulin

S Alakurtti, T Mäkelä, S Koskimies… - European journal of …, 2006 - Elsevier
Betulin (lup-20 (29)-ene-3β, 28-diol) is an abundant naturally occurring triterpene and it is
found predominantly in bushes and trees forming the principal extractive (up to 30% of dry …

Terpenes: substances useful in human healthcare

R Paduch, M Kandefer-Szerszeń, M Trytek… - Archivum immunologiae …, 2007 - Springer
Terpenes are naturally occurring substances produced by a wide variety of plants and
animals. A broad range of the biological properties of terpenoids is described, including …

Betulinic acid for cancer treatment and prevention

S Fulda - International journal of molecular sciences, 2008 - mdpi.com
Betulinic acid is a natural product with a range of biological effects, for example potent
antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell …

Birch bark research and development

PA Krasutsky - Natural product reports, 2006 - pubs.rsc.org
Covering: 1995 to 2006 This review will detail progress made in the previous decade on the
chemistry and bioactivity of birch bark extractive products. Current and future applications of …