Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Cancer cells exist in a mechanically and chemically heterogeneous microenvironment
which undergoes dynamic changes throughout neoplastic progression. During metastasis …

Cell invasion through a dense three-dimensional (3D) matrix is believed to depend on the
ability of cells to generate traction forces. To quantify the role of cell tractions during invasion …

In cancer metastasis and other physiological processes, cells migrate through the three-
dimensional (3D) extracellular matrix of connective tissue and must overcome the steric …

Cell migration through connective tissue, or cell invasion, is a fundamental biomechanical
process during metastasis formation. Cell invasion usually requires cell adhesion to the …

The migration and invasion of cancer cells through 3D confined extracellular matrices is
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …