The central role of dysregulated kinase activity in the etiology of progressive disorders,
including cancer, has fostered incremental efforts on drug discovery programs over the past …

The advent of organic synthesis and the understanding of the molecule as they occurred in
the nineteenth century and were refined in the twentieth century constitute two of the most …

Interest in green chemistry and clean processes has grown so much in recent years that
topics such as fluorous biphasic catalysis, metal organic frameworks, and process …

Umpolung-based strategies play a significant role in organic synthesis. Particularly
important are 1, 3-dithiane linchpins, which serve as convenient acyl anion equivalents. The …

1. Introduction 2. Reductive Desulfonylation 2.1. Replacement of the sulfone group by
hydrogen 2.1. 1. Alkyl sulfones 2.1. la ct-Functionalised alkyl sulfones 2.1. 1. b. Other …

Trisubstituted alkenes have been prepared for the first time via intermolecular olefin cross-
metathesis, using 1, 3-dimesityl-4, 5-dihydroimidazol-2-ylidene ruthenium alkylidene …

Erythromycin and rapamycin are both macrolide antibiotics. 1, 2 Erythromycin A (1) belongs
to a large family of macrolides which are characterized by rings containing 12, 14, or 16 …

The normal reactivity of a carbonyl compound (I) is as an a 1-reagent (II) and the temporary
reversal of the characteristic pattern of reactivity of a functional group is described by the …

In 1995, Uemura and co-workers isolated pinnatoxin A (1) from the shellfish Pinna muricata,
determined its gross structure and relative stereochemistry, and proposed a biosynthetic …

The synthesis of the marine neurotoxin azaspiracid-1 has been accomplished. The
individual fragments were synthesized by catalytic enantioselective processes: A hetero …