Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Volatile general anesthetics continue to be an important part of clinical anesthesia
worldwide. The impact of volatile anesthetics on the immune system has been investigated …

Perioperative acute kidney injury (AKI) is not uncommon and is associated with
considerable morbidity and mortality. Recently, several definition systems for AKI were …

Background: Acute renal dysfunction (ARD) and subsequent acute renal failure after cardiac
surgery are associated with high mortality and morbidity. Early therapeutic or preventive …

Objective To assess the effects of sevoflurane, the most commonly used inhalation
anesthetic, on apoptosis and β-amyloid protein (Aβ) levels in vitro and in vivo. Subjects …

Acute kidney injury (AKI) is an underestimated, yet important risk factor for development of
chronic kidney disease (CKD). Even after initial total recovery of renal function, some …

Acute kidney injury, a common complication of cardiac surgery with cardiopulmonary
bypass, is associated with increased morbidity and mortality. Ischemic preconditioning at a …

EACTS Clinical Guidelines Committee Members: Miguel Sousa-Uva (Chairperson)(Portugal
), Umberto Benedetto (UK), Giuseppe Cardillo (Italy), Manuel Castella (Spain), Martin …

Background: Adhesion of polymorphonuclear neutrophils and platelets to the vessel wall
contributes to generating ischemia–reperfusion injury. Endothelial adhesion molecules are …

Acute kidney injury (AKI) is a common and serious complication of cardiac surgery. It is
associated with increased morbidity and mortality. On a population level, the financial impact …