Today, the average life expectancy in developed nations is over 80 years and climbing. And
yet, the quality of life during those additional years is often significantly diminished by the …

This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …

Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the
complement system in plasma and in the protection of bystander host cells and tissues from …

Background: Adrenomedullin (ADM) is a potent vasodilatory peptide, and circulating
concentrations have been described for several disease states, including dysfunction of the …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Introduction Measurement of biomarkers is a potential approach to early assessment and
prediction of mortality in patients with sepsis. The aim of the present study was to evaluate …

Introduction Pro-adrenomedullin (proADM) is helpful for individual risk assessment and
outcome prediction in sepsis. A major cause of sepsis is community-acquired pneumonia …

Adrenomedullin and PAMP are potent vasodilatory peptides derived from a common larger
precursor peptide. Elevation of circulating levels of both peptides has been described for …

The first clinical signs of sepsis are usually unspecific (eg, fever or leukocytosis). More
specific symptoms, such as arterial hypotension or raised lactate, often indicate progression …

Sepsis remains a major medical challenge, for which, apart from improvements in supportive
care, treatment has not relevantly changed over the last few decades. Vasodilation and …