Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

The global pandemic of coronavirus disease 2019 (COVID‐19) is associated with the
development of acute respiratory distress syndrome (ARDS), which requires ventilation in …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

Idiopathic pulmonary fibrosis (IPF) is one of a group of interstitial lung diseases that are
characterized by excessive matrix deposition and destruction of the normal lung …

Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

The Hippo signaling pathway plays a crucial role in tissue growth and tumorigenesis. Core
components of the Hippo pathway include the MST1/2 and Lats1/2 kinases. Acting …

The challenge facing many fibrotic lung diseases is that these conditions usually present
late, often after several decades of repetitive alveolar epithelial injury, during which …

Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …

Connective tissue growth factor (CTGF, CCN2) is a secreted protein with major roles in
angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis. It is a …